{"id":7311,"date":"2024-01-24T06:50:48","date_gmt":"2024-01-24T05:50:48","guid":{"rendered":"https:\/\/kompetenz-statt-demenz.dsgip.de\/?p=7311"},"modified":"2024-01-22T14:54:49","modified_gmt":"2024-01-22T13:54:49","slug":"ksd-news-and-news-from-around-the-world-2","status":"publish","type":"post","link":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/ksd-news-and-news-from-around-the-world-2\/","title":{"rendered":"KsD up to date: Reports and news from around the world"},"content":{"rendered":"<p><span data-contrast=\"auto\">To kick off the year, we would like to draw your attention once again to current articles from the Internet that are closely related to our core topic of lifestyle-oriented and responsible prevention and treatment of dementia and its relevance. The opinions expressed there serve as a stimulus for critical debate. They do not necessarily correspond to the positions we represent, but in all cases they enrich the basis for discussion. We also refer to the cited, freely available studies at the end &#8211; see for yourself!<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3><a href=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/gehirn\/12-massnahmen-forscher-finden-fuenf-verschiedene-arten-von-alzheimer-wie-sie-sich-schuetzen_id_259567453.html\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Researchers find five different types of Alzheimer&#8217;s &#8211; how to protect yourself<\/span><span data-contrast=\"auto\"> (Focus.de 1\/21\/2024)<\/span> <\/a><\/h3>\n<p><span data-contrast=\"auto\">Not all Alzheimer&#8217;s is the same: researchers have identified five different subtypes. These could help to develop more targeted therapies in the future and explain why current Alzheimer&#8217;s drugs are only partially effective.<\/span><\/p>\n<p><i><span data-contrast=\"auto\">(These new findings emphasize the importance of a <\/span><\/i><a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/praevention-behandlung\/\" target=\"_blank\" rel=\"noopener\"><i><span data-contrast=\"none\">personalized individual therapy approach <\/span><\/i><\/a><i><span data-contrast=\"auto\">for Alzheimer&#8217;s disease)<\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<h3><a href=\"https:\/\/www.wissenschaft.de\/gesundheit-medizin\/neue-ursache-fuer-alzheimer-entdeckt\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">New cause of Alzheimer&#8217;s disease discovered<\/span><span data-contrast=\"auto\"> (Bild der Wissenschaft 19.01.2024)<\/span> <\/a><\/h3>\n<p><span data-contrast=\"auto\">Large numbers of nerve cells die off in the brains of Alzheimer&#8217;s patients. This can have various triggers. Researchers have now discovered a new culprit: short RNA sequences (sRNA) that have a toxic effect on neurons. At the same time, sRNAs with a protective effect are less common in older brains and in Alzheimer&#8217;s disease, the study found. Accordingly, a disbalance of these two types of sRNA molecules could be responsible for neuronal death. This knowledge helps to better understand the disease and opens up new possibilities for drugs against neurodegenerative diseases.<\/span><\/p>\n<p><i><span data-contrast=\"auto\">(This makes it clear how important active <\/span><\/i><a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/praevention-behandlung\/\" target=\"_blank\" rel=\"noopener\"><i><span data-contrast=\"none\">lifestyle-oriented dementia prevention <\/span><\/i><\/a><i><span data-contrast=\"auto\">is for a healthy molecular balance in the brain). <\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<h3><a href=\"https:\/\/www.nationalgeographic.de\/geschichte-und-kultur\/2024\/01\/einzigartige-gen-datenbank-multiple-sklerose-alzheimer-nach-europa-wanderung\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Unique gene database: How multiple sclerosis and Alzheimer&#8217;s came to Europe<\/span><span data-contrast=\"auto\"> (National Geographic 19.01.2024)<\/span> <\/a><\/h3>\n<p><span data-contrast=\"auto\">Our ancestors suffered from chronic diseases thousands of years ago. A research project shows where the origins of the diseases lie and why they are now more widespread in certain regions of Europe than in others.<\/span><\/p>\n<p><i><span data-contrast=\"auto\">(At the KsD you can find out in detail about the <\/span><\/i><a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/genetik\/\" target=\"_blank\" rel=\"noopener\"><i><span data-contrast=\"none\">genetic influencing factors in Alzheimer&#8217;s disease <\/span><\/i><\/a><i><span data-contrast=\"auto\">information)<\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<h3><a href=\"https:\/\/www.merkur.de\/welt\/therapie-leqembi-donanemab-medikamente-alzheimer-medizin-gesundheit-zr-92767390.html\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Alzheimer&#8217;s breakthrough thanks to donanemab and Leqembi? German experts warn of serious side effects<\/span><span data-contrast=\"auto\"> (Merkur.de 11.01.2024)<\/span> <\/a><\/h3>\n<p><span data-contrast=\"auto\">Leqembi and donanemab show promising results in the treatment of Alzheimer&#8217;s disease. But there are also serious side effects.<\/span><\/p>\n<p><i><span data-contrast=\"auto\">(More evidence-based information beyond the interests of <\/span><\/i><i><span data-contrast=\"auto\">interests of the pharmaceutical companies can be found at the KsD under <\/span><\/i><a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/therapeuten-behandlung\/behandlungsformen\/monoklonale-antikoerper\/\" target=\"_blank\" rel=\"noopener\"><i><span data-contrast=\"none\">antibody drugs<\/span><\/i><\/a><i><span data-contrast=\"auto\">)<\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<h3><a href=\"https:\/\/www.charite.de\/service\/pressemitteilung\/artikel\/detail\/infektion_mit_magenkeim_koennte_alzheimer_risiko_erhoehen\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Infection with stomach germ could increase Alzheimer&#8217;s risk<\/span><span data-contrast=\"auto\"> (Press release <\/span><span data-contrast=\"auto\">Charit\u00e9<\/span><span data-contrast=\"auto\"> Berlin 13.12.2023)<\/span> <\/a><\/h3>\n<p><span data-contrast=\"auto\">Infection with the stomach germ <\/span><i><br \/>\n<span data-contrast=\"auto\">Helicobacter pylori<\/span><br \/>\n<\/i><span data-contrast=\"auto\"> could increase the risk of Alzheimer&#8217;s dementia: In people over the age of 50, the risk can be increased by an average of 11 percent after infection with symptoms, and by as much as 24 percent around ten years after infection. This is suggested by the results of a study by Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin and McGill University (Canada), which have now been published in the specialist journal Alzheimer&#8217;s &amp; Dementia. The researchers analyzed patient data from three decades.<\/span><\/p>\n<p><i><span data-contrast=\"auto\">(The article confirms that a healthy <\/span><\/i><a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/gehirn-koerper\/darm-mikrobiota\/\" target=\"_blank\" rel=\"noopener\"><i><span data-contrast=\"none\">bacterial colonization of the mucous membranes of the digestive tract <\/span><\/i><\/a><i><span data-contrast=\"auto\">is an essential factor in the prevention of dementia)<\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<h3><a href=\"https:\/\/www.bionity.com\/de\/news\/1181651\/kann-kaffee-das-gedaechtnis-verbessern.html\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Can coffee improve memory?<\/span><span data-contrast=\"auto\"> (Bionity 27.09.2023)<\/span> <\/a><\/h3>\n<p><span data-contrast=\"auto\">Trigonelline extracted from coffee could improve spatial learning memory in old age. <\/span><span data-contrast=\"auto\">D<\/span><span data-contrast=\"auto\">he search for functional natural substances that can improve age-related cognitive decline has recently become an important focus of research to promote healthy ageing. Trigonelline (TG), a plant alkaloid found in coffee, fenugreek seeds and radish, was expected to have cognitive properties. <\/span><\/p>\n<p><i><span data-contrast=\"auto\">(Find out from the KsD which other <\/span><\/i><a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/praevention-behandlung\/ernaehrung\/\" target=\"_blank\" rel=\"noopener\"><i><span data-contrast=\"none\">plant substances <\/span><\/i><\/a><i><span data-contrast=\"auto\"> besides trigonelline have a positive effect on the risk of dementia according to studies).<\/span><\/i><\/p>\n<p>&nbsp;<\/p>\n<div style=\"background-color: #f2f2f2; padding: 10px;\">Among these press releases, one piece of news caught our eye: The <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-44465-8\" target=\"_blank\" rel=\"noopener\">study<\/a> published a few days ago in <i>Nature Communications<\/i> (reported by Bild der Wissenschaft above) describes how important the molecular balance between toxic and protective molecules in the brain is. You can imagine this as a scale: If one side of these scales is too heavily weighted, the balance is upset and this state has long-term negative health consequences. If the toxic molecules are constantly present, the neurons are encouraged to die, increasing the risk of developing Alzheimer&#8217;s disease. However, if the toxic side is permanently suppressed, the organism loses its natural immunological protective functions against cancer. Unilateral intervention with medication in this finely tuned endogenous system would therefore certainly be a wrong measure. Especially as it is already known that there are effective and side-effect-free <a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/therapeuten-behandlung\/behandlungsformen\/recode-bredesen\/\" target=\"_blank\" rel=\"noopener\">lifestyle-oriented prevention and therapy concepts<\/a> that maintain precisely these molecular balances in the brain and safeguard your mental health in the long term!<\/div>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"none\">With this in mind, we from the team at &#8220;<\/span><a href=\"https:\/\/kompetenz-statt-demenz.dsgip.de\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Knowledge stops Dementia<\/span><\/a><span data-contrast=\"none\">&#8221; wish you a good start into a happy, peaceful and above all healthy 2024!<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>References: <\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Paudel, B., Jeong, SY., Martinez, C.P. <\/span><i><span data-contrast=\"none\">et al. <\/span><\/i><span data-contrast=\"none\">Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer&#8217;s disease and aging. <\/span><i><span data-contrast=\"none\">Nat Commun <\/span><\/i><span data-contrast=\"none\">15, 264 (2024). <\/span><a href=\"https:\/\/doi.org\/10.1038\/s41467-023-44465-8\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s41467-023-44465-8<\/span><\/a><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Douros, A., Ante, Z., Fallone, C. A., Azoulay, L., Renoux, C., Suissa, S., &amp; Brassard, P. (2023). Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer&#8217;s disease: A population-based nested case-control study.<\/span><i><span data-contrast=\"none\">Alzheimer&#8217;s &amp; Dementia<\/span><\/i><span data-contrast=\"none\">. <\/span> <a href=\"https:\/\/doi.org\/10.1002\/alz.13561\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1002\/alz.13561<\/span><\/a><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Tijms, B.M., Vromen, E.M., Mjaavatten, O. <\/span><i><span data-contrast=\"none\">et al.<\/span><\/i> <span data-contrast=\"none\">Cerebrospinal fluid proteomics in patients with Alzheimer\u2019s disease reveals five molecular subtypes with distinct genetic risk profiles. <\/span><i><span data-contrast=\"none\">Nat Aging<\/span><\/i><span data-contrast=\"none\"> 4, 33\u201347 (2024). <\/span><a href=\"http:\/\/Tijms,%20B.M.,%20Vromen,%20E.M.,%20Mjaavatten,%20O.%20et%20al.%20Cerebrospinal%20fluid%20proteomics%20in%20patients%20with%20Alzheimer%E2%80%99s%20disease%20reveals%20five%20molecular%20subtypes%20with%20distinct%20genetic%20risk%20profiles.%20Nat%20Aging%204,%2033%E2%80%9347%20(2024).%20https:\/doi.org\/10.1038\/s43587-023-00550-7\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">https:\/\/doi.org\/10.1038\/s43587-023-00550-7<\/span><\/a><\/li>\n<\/ul>\n<p><strong>Image by:<\/strong> <a href=\"https:\/\/pixabay.com\/de\/users\/viarami-13458823\/\" target=\"_blank\" rel=\"noopener\">viarami<\/a> from <a href=\"https:\/\/pixabay.com\/de\/\" target=\"_blank\" rel=\"noopener\">pixabay<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>At regular intervals, we would like to draw your attention to current articles from the Internet that are closely related to our core topic of lifestyle-oriented and self-responsible prevention and treatment of dementia and their relevance. The opinions expressed in the above articles are intended to serve as a stimulus for critical debate. They do not necessarily correspond to the positions we represent, but in all cases they enrich the basis for discussion. At the end of each press article we refer to our scientifically based KsD articles &#8211; please take a look for yourself!  <\/p>\n","protected":false},"author":12,"featured_media":7305,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[78,62,147],"tags":[],"class_list":["post-7311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-causes","category-forms-of-treatment","category-prevention-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/posts\/7311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/comments?post=7311"}],"version-history":[{"count":5,"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/posts\/7311\/revisions"}],"predecessor-version":[{"id":7316,"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/posts\/7311\/revisions\/7316"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/media\/7305"}],"wp:attachment":[{"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/media?parent=7311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/categories?post=7311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kompetenz-statt-demenz.dsgip.de\/en\/wp-json\/wp\/v2\/tags?post=7311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}