Spermidine, also known chemically as N-(3-aminopropyl) butane-1,4-diamine, is one of the naturally occurring polyamines. It occurs as a natural substance in amino acid metabolism of all living organisms and in all cells, and therefore also in a variety of plant and animal foods. Particularly rich food sources are wheat germ, but hard cheese, dried soybeans and some other foods also provide good amounts of spermidine. Recently, it was shown in mice that spermidine from food actually reaches the brain, thus crossing the blood-brain barrier.
Ashwagandha (Withania somnifera), also known as Indian ginseng or Winter cherry, is one of the most important herbs in Ayurvedic medicine. It has been used for millennia as a rejuvenating tonic, i.e. to increase physical and mental health by promoting longevity. Classically, different parts of the plant (including roots, leaves and flowers) have been used to treat different conditions such as rheumatism, constipation, insomnia, chronic stress and hormonal imbalances. Recently, the benefits of this herb have aroused the interest of conventional western medicine and in the last 10 years many studies have been published bringing scientific evidence for what the ancients used to practice many years ago.
Red wine drinkers are generally good-natured people and known for mastering life with pleasure and relaxation. These alone are two protective factors against dementia, because stress is poison for the brain (but more about this later on). In addition, a secondary plant substance present particularly in red wine is increasingly attracting the interest of research and prevention in Alzheimer's disease: resveratrol.
The benefits of curcumin in different organ systems have been extensively documented in the past in several neurological diseases and cancer. Curcumin has received worldwide recognition for its potent antioxidant, anti-inflammatory, anti-cancer and antimicrobial activities. Curcumin has been successfully used to treat diabetes and arthritis, as well as liver, kidney and cardiovascular diseases. Recently, attention has focused on the use of curcumin to prevent or delay the onset of neurodegenerative diseases.