KsD up to date: Reports and news from around the world

3.6 min readPublished On: 24. January 2024By Categories: causes, forms of treatment, Prevention

To kick off the year, we would like to draw your attention once again to current articles from the Internet that are closely related to our core topic of lifestyle-oriented and responsible prevention and treatment of dementia and its relevance. The opinions expressed there serve as a stimulus for critical debate. They do not necessarily correspond to the positions we represent, but in all cases they enrich the basis for discussion. We also refer to the cited, freely available studies at the end – see for yourself!

 

Researchers find five different types of Alzheimer’s – how to protect yourself (Focus.de 1/21/2024)

Not all Alzheimer’s is the same: researchers have identified five different subtypes. These could help to develop more targeted therapies in the future and explain why current Alzheimer’s drugs are only partially effective.

(These new findings emphasize the importance of a personalized individual therapy approach for Alzheimer’s disease)

 

New cause of Alzheimer’s disease discovered (Bild der Wissenschaft 19.01.2024)

Large numbers of nerve cells die off in the brains of Alzheimer’s patients. This can have various triggers. Researchers have now discovered a new culprit: short RNA sequences (sRNA) that have a toxic effect on neurons. At the same time, sRNAs with a protective effect are less common in older brains and in Alzheimer’s disease, the study found. Accordingly, a disbalance of these two types of sRNA molecules could be responsible for neuronal death. This knowledge helps to better understand the disease and opens up new possibilities for drugs against neurodegenerative diseases.

(This makes it clear how important active lifestyle-oriented dementia prevention is for a healthy molecular balance in the brain).

 

Unique gene database: How multiple sclerosis and Alzheimer’s came to Europe (National Geographic 19.01.2024)

Our ancestors suffered from chronic diseases thousands of years ago. A research project shows where the origins of the diseases lie and why they are now more widespread in certain regions of Europe than in others.

(At the KsD you can find out in detail about the genetic influencing factors in Alzheimer’s disease information)

 

Alzheimer’s breakthrough thanks to donanemab and Leqembi? German experts warn of serious side effects (Merkur.de 11.01.2024)

Leqembi and donanemab show promising results in the treatment of Alzheimer’s disease. But there are also serious side effects.

(More evidence-based information beyond the interests of interests of the pharmaceutical companies can be found at the KsD under antibody drugs)

 

Infection with stomach germ could increase Alzheimer’s risk (Press release Charité Berlin 13.12.2023)

Infection with the stomach germ
Helicobacter pylori
could increase the risk of Alzheimer’s dementia: In people over the age of 50, the risk can be increased by an average of 11 percent after infection with symptoms, and by as much as 24 percent around ten years after infection. This is suggested by the results of a study by Charité – Universitätsmedizin Berlin and McGill University (Canada), which have now been published in the specialist journal Alzheimer’s & Dementia. The researchers analyzed patient data from three decades.

(The article confirms that a healthy bacterial colonization of the mucous membranes of the digestive tract is an essential factor in the prevention of dementia)

 

Can coffee improve memory? (Bionity 27.09.2023)

Trigonelline extracted from coffee could improve spatial learning memory in old age. Dhe search for functional natural substances that can improve age-related cognitive decline has recently become an important focus of research to promote healthy ageing. Trigonelline (TG), a plant alkaloid found in coffee, fenugreek seeds and radish, was expected to have cognitive properties.

(Find out from the KsD which other plant substances besides trigonelline have a positive effect on the risk of dementia according to studies).

 

Among these press releases, one piece of news caught our eye: The study published a few days ago in Nature Communications (reported by Bild der Wissenschaft above) describes how important the molecular balance between toxic and protective molecules in the brain is. You can imagine this as a scale: If one side of these scales is too heavily weighted, the balance is upset and this state has long-term negative health consequences. If the toxic molecules are constantly present, the neurons are encouraged to die, increasing the risk of developing Alzheimer’s disease. However, if the toxic side is permanently suppressed, the organism loses its natural immunological protective functions against cancer. Unilateral intervention with medication in this finely tuned endogenous system would therefore certainly be a wrong measure. Especially as it is already known that there are effective and side-effect-free lifestyle-oriented prevention and therapy concepts that maintain precisely these molecular balances in the brain and safeguard your mental health in the long term!

 

With this in mind, we from the team at “Knowledge stops Dementia” wish you a good start into a happy, peaceful and above all healthy 2024!

 

References:

  • Paudel, B., Jeong, SY., Martinez, C.P. et al. Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging. Nat Commun 15, 264 (2024). https://doi.org/10.1038/s41467-023-44465-8
  • Douros, A., Ante, Z., Fallone, C. A., Azoulay, L., Renoux, C., Suissa, S., & Brassard, P. (2023). Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer’s disease: A population-based nested case-control study.Alzheimer’s & Dementia. https://doi.org/10.1002/alz.13561
  • Tijms, B.M., Vromen, E.M., Mjaavatten, O. et al. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles. Nat Aging 4, 33–47 (2024). https://doi.org/10.1038/s43587-023-00550-7

Image by: viarami from pixabay

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