Forms of treatment

New Alzheimer’s drug aducanumab: far-reaching implications of a controversial approval

By |2021-07-12T20:28:44+02:0013. July 2021|Categories: clinical trial, Forms of treatment|

Positive news from clinical Alzheimer's research is rare. In hardly any other indication do pharmaceutical companies have to accept as many setbacks as here. To date, pharmacological approaches to treating Alzheimer's have been almost uniformly unsuccessful, with more than 400 failed clinical trials. Since 2002, there has been no new approval in the field of neurodegenerative diseases.     That changed on June 7, 2021, when the drug Aducanumab, from U.S. biotech Biogen (and its Japanese research partner Eisai), was approved by the U.S. Food and Drug Administration (FDA) for the treatment of Alzheimer's disease. The drug, which is administered intravenously to patients, will be available in the U.S. under the trade mark Aduhelm.     Aduhelm works on the basis of passive immunization. It is a monoclonal antibody that targets amyloid-ß, a protein characteristic of Alzheimer's disease. These amyloid-ß proteins make up the deposits in the brain, known as plaques, which are associated with the destruction of neurones. Aduhelm's mechanism of action is based on promoting the breakdown of β-amyloid, thereby reducing the harmful plaques.  

Galactose as a therapeutic sugar alternative for Alzheimer’s dementia?

By |2021-06-22T10:34:10+02:0023. June 2021|Categories: Causes, Forms of treatment, nutrition, Prävention, prevention|

It has been known for quite some time that a disturbance in blood glucose and insulin metabolism plays a central role not only in diabetes, but also in Alzheimer's disease. When insulin, which is important for glucose utilization, can no longer work properly due to missing or damaged insulin receptors, the so-called insulin resistance occurs. This also applies to the brain, where it is called cerebral insulin resistance. If this occurs, our central nervous system may experience an energy deficiency despite high glucose levels in the blood. The resulting starvation state of the brain gradually leads to the cessation of its specific functions and the death of brain cells, which is particularly noticeable in the impairment of memory. Therefore, maintaining or restoring the energy metabolism of the brain is of crucial importance, especially at the beginning of Alzheimer's disease.   

Clinical trial proves potential reversal of cognitive decline in early Alzheimer’s disease

By |2021-09-06T13:18:02+02:002. June 2021|Categories: clinical trial, Forms of treatment|

It's been a long road for Dr. Dale Bredesen in Alzheimer's research: He worked for years as a scientist and studied dying brain cells, fruit flies with "Alzflymer" and transgenic mice with "Mouzheimer's." But his applications for clinical trials that could demonstrate proof of efficacy of his research concepts in patients were first rejected in 2011 and again in 2018. Instead, he published treatment successes in his patients in 2014, 2016 and 2018. Finally, in 2019, he received approval to conduct a clinical trial, which was then completed last year.  

Awakening from deep dementia: favourite music as the key to memory

By |2021-05-11T17:03:49+02:0012. May 2021|Categories: clinical trial, Forms of treatment, Prävention, prevention|

It seems like a miracle: a late-stage Alzheimer's patient, completely immersed in dementia and cut off from his environment and his own identity. But when he hears the sounds of familiar pieces of music selected for him from his former life, he wakes up from his apathy, starts to laugh, talk, move and becomes 'alive' again!

Early Alzheimer’s symptoms are reversible: current lifestyle intervention shows promising results

By |2021-04-21T09:52:21+02:0021. April 2021|Categories: Causes, clinical trial, Forms of treatment, nutrition, Prävention, prevention|

The relation between lifestyle and Alzheimer’s disease has been previously described in many studies. It has become well established that lifestyle interventions can prevent the onset of the disease in about 40% (as we reported in a previous NF based on the 12 Alzheimer’s disease prevention factors listed by The Lancet commission on Dementia). The Finnish FINGER study (Finnish Geriatric Intervention Study 2015) has also already impressively shown these correlations 

Can aerobic exercises reduce cognitive decline in Alzheimer’s patients? – Results from a new randomized controlled trial.

By |2021-04-10T13:48:16+02:0031. March 2021|Categories: clinical trial, Forms of treatment, Prävention|

Physical exercise is an important part of a healthy lifestyle, contributing to general fitness, muscle control and coordination, and to a sense of wellbeing. Physical exercise is also essential for maintaining adequate blood flow to the brain and may stimulate brain cell growth and survival. Evidence of the effects of physical exercise in the prevention of dementia have been supported by many observational studies. The results of randomized trials suggest that exercise leads to increases in brain tissue, including the hippocampus and elevate blood levels of brain derived neurotrophic factor (BDNF), stimulating the formation of new nerve cells.

The ReCode program according to Dr. Bredesen – Cure for Alzheimer’s disease is possible

By |2021-03-09T18:55:24+01:0010. March 2021|Categories: Causes, Forms of treatment|

To date, there is no effective drug to treat Alzheimer's disease. The currently available drug treatment options are limited to acetylcholinesterase inhibitors and memantines, each of which is used depending on the stage of the disease and directly influences the action of neurotransmitters in the brain. It is hard to believe, but these pharmacological approaches are still based on the findings of the 1970s and 1980s. 

Ashwagandha: How can this powerful adaptogen prevent dementia?

By |2021-01-26T19:41:58+01:0027. January 2021|Categories: Forms of treatment, plant substances|

Ashwagandha (Withania somnifera), also known as Indian ginseng or Winter cherry, is one of the most important herbs in Ayurvedic medicine. It has been used for millennia as a rejuvenating tonic, i.e. to increase physical and mental health by promoting longevity. Classically, different parts of the plant (including roots, leaves and flowers) have been used to treat different conditions such as rheumatism, constipation, insomnia, chronic stress and hormonal imbalances. Recently, the benefits of this herb have aroused the interest of conventional western medicine and in the last 10 years many studies have been published bringing scientific evidence for what the ancients used to practice many years ago.

Nutritional drink against early-stage Alzheimer’s? First non-pharmacological study to show long-term success.

By |2021-01-12T18:52:25+01:0013. January 2021|Categories: Causes, clinical trial, Forms of treatment, micronutrient deficiencies, nutrition, Prävention, prevention, Uncategorized|

Can the course of early Alzheimer's disease be delayed by consuming a special mixture of nutrients? This question was investigated in the European study called 'LipiDiDiet' led by Prof. Tobias Hartmann.  The scientists recruited Alzheimer's patients, who were in the early stages of the disease, to test the effectiveness of a specific nutritional drink called 'Souvenaid'. Souvenaid was developed as a medical dietary food for the treatment of early-stage Alzheimer's disease and is marketed by Nutricia (Danone Group). It contains a defined nutrient combination of long-chain omega-3 fatty acids, phospholipids, choline, B vitamins (B6, B12 and folic acid), vitamins C and E, selenium and uridine monophosphate. 

Always stay in touch – How speech therapy helps people with dementia and their families 

By |2020-11-24T18:15:24+01:0025. November 2020|Categories: Forms of treatment, Prävention, prevention, therapists|

With the project ‘Knowledge stops Dementia’, the Deutsche Stiftung für Gesundheitsinformation und Prävention, together with the Akademie für menschliche Medizin, presents a broad spectrum of measures to prevent the development of dementia. Within preventive measures, speech therapy offers an important therapeutic component that enables dementia patients to maintain contact with their environment. Especially in the early stages of the disease, no time should be lost and no one should hesitate to seek speech therapy treatment. 

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