Recent study shows: Antibody drugs for Alzheimer’s shrink the brain
An Australian study found that antibody drugs for Alzheimer's, such as aducanumab and lecanemab, can reduce brain volumes. Despite successful reduction of Alzheimer's-specific amyloid-beta deposits, the benefit of these drugs remains questionable. They slow cognitive decline only slightly and have severe side effects. The study also suggests that these drugs promote the cardinal structural symptom of Alzheimer's disease, brain atrophy. Thus, they increase the risk of brain tissue loss, a direct cause of cognitive decline in Alzheimer's disease.